Transcriptome analysis of Homo sapiens and Mus musculus reveals mechanisms of CD8+ T cell exhaustion caused by different factors.
T cell exhaustion is a state of T cell dysfunction during chronic infection and cancer.Antibody-targeting immune checkpoint inhibitors to reverse T cell exhaustion is a promising approach for cancer Musculoskeletal Health immunotherapy.However, molecular mechanisms of T cell exhaustion remain incompletely understood.Here, we performed a transcripto